Research use only. For in-vitro and laboratory research. Not for human or veterinary use. No aliquoting guidance is provided.

FOXO4-DRI Research Video Explainer

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This short video explains FOXO4-DRI as a research compound. FOXO4-DRI is D-Retro-Inverso Peptide Studied in FOXO4–p53 Senescent Cell Signalling. It covers its molecular identity (CAS 2460055-10-9, 5358.00 g/mol) and the pathways studied in laboratory models. For in-vitro and laboratory research use only. Not for human or veterinary use.

Identity

What researchers study it for

• Studying selective disruption of the nuclear FOXO4–p53 protein–protein interaction in senescent cells.
• Investigating D-retro-inverso stereochemistry resistance against intracellular proteolytic cleavage.
• Examining Senescence-Associated Secretory Phenotype (SASP) attenuation in pre-clinical ageing models.

How it is studied to work

• 1. HIV-TAT Cell-Penetrating Entry Crosses the plasma and nuclear membranes via its N-terminal TAT basic translocation motif.
• 2. Competitive FOXO4–p53 Displacement Binds the p53 transactivation domain with high affinity, freeing p53 from FOXO4 nuclear foci.
• 3. Nuclear Exclusion & Intrinsic Apoptosis Phosphorylated p53 translocates to mitochondria, triggering caspase-3/7 apoptosis in senescent cells.

Product and lab links

FOXO4-DRI vials and specification Verify your batch All peptide videos

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Corex Vitality™ supplies research peptides for laboratory use only. This page is an educational explainer of molecular identity and published research pathways. It is not medical advice and does not recommend human use.