Research use only. For in-vitro and laboratory research. Not for human or veterinary use. No aliquoting guidance is provided.

Dulaglutide Research Video Explainer

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This short video explains Dulaglutide as a research compound. Dulaglutide is DPP-4-Resistant GLP-1(7-37) Covalent Analogue Reference Compound. It covers its molecular identity (CAS 923950-08-7, 59669.80 g/mol (Homodimer)) and the pathways studied in laboratory models. For in-vitro and laboratory research use only. Not for human or veterinary use.

Identity

What researchers study it for

• Studying Gly8, Glu22 and Gly36 amino-acid substitutions that confer structural resistance to DPP-4 cleavage.
• Comparing macromolecular FcRn recycling and steric shielding against small-peptide fatty-acid acylation.
• Investigating sustained GLP-1 receptor cAMP accumulation and beta-cell membrane depolarisation in vitro.

How it is studied to work

• 1. Bivalent GLP-1R Domain Engagement Presents two DPP-4-resistant GLP-1(7-37) active domains via flexible (Gly4Ser)3 peptide linkers.
• 2. Position-8 Glycine DPP-4 Protection Ala8→Gly8 substitution blocks dipeptidyl peptidase-4 N-terminal inactivation while Glu22 stabilises helicity.
• 3. Intracellular cAMP / PKA Activation Stimulates membrane adenylyl cyclase to elevate cAMP, closing KATP channels and mobilising intracellular Ca2+.

Lab links

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Corex Vitality™ supplies research peptides for laboratory use only. This page is an educational explainer of molecular identity and published research pathways. It is not medical advice and does not recommend human use.