Research use only. For in-vitro and laboratory research. Not for human or veterinary use. No aliquoting guidance is provided.

5-Amino-1MQ Research Video Explainer

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This short video explains 5-Amino-1MQ as a research compound. 5-Amino-1MQ is Selective NNMT (Nicotinamide N-Methyltransferase) Small-Molecule Inhibitor. It covers its molecular identity (CAS 42464-96-0, 159.21 g/mol) and the pathways studied in laboratory models. For in-vitro and laboratory research use only. Not for human or veterinary use.

Identity

What researchers study it for

• Studying selective inhibition of Nicotinamide N-Methyltransferase (NNMT, IC50 ~1.2 uM) in adipocyte & muscle cultures.
• Investigating intracellular NAD+ salvage pathway conservation and S-adenosylmethionine (SAM) methyl-donor balance.
• Examining SIRT1 deacetylase activation, GLUT4 expression and lipogenesis suppression in white adipose models.

How it is studied to work

• 1. Competitive NNMT Active-Site Block Binds the nicotinamide pocket of NNMT, preventing methylation of nicotinamide into 1-methylnicotinamide (1-MNA).
• 2. Intracellular NAD+ & SAM Preservation Spares nicotinamide for NAMPT-mediated NAD+ salvage while preserving cellular SAM/SAH methylation ratios.
• 3. SIRT1 & Mitochondrial Activation Elevated NAD+ activates Sirtuin-1 (SIRT1) and PGC-1alpha, increasing cellular oxidative metabolism in vitro.

Lab links

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Corex Vitality™ supplies research peptides for laboratory use only. This page is an educational explainer of molecular identity and published research pathways. It is not medical advice and does not recommend human use.