Research use only. For in-vitro and laboratory research. Not for human or veterinary use. No aliquoting guidance is provided.

AHK-Cu Research Video Explainer

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This short video explains AHK-Cu as a research compound. AHK-Cu is Copper(II)-Complexed Ala-His-Lys Dermal & Follicular ECM Research Peptide. It covers its molecular identity (CAS 682809-81-0, 416.92 g/mol) and the pathways studied in laboratory models. For in-vitro and laboratory research use only. Not for human or veterinary use.

Identity

What researchers study it for

• Studying dermal papilla fibroblast proliferation, VEGF synthesis and extracellular matrix remodelling in vitro.
• Investigating TGF-beta1 / Dickkopf-1 (DKK-1) ratio modulation and anti-apoptotic Bcl-2/Bax signalling in follicular models.
• Comparing Ala-His-Lys-Cu(II) vs Gly-His-Lys-Cu(II) copper transport kinetics and Type I/III collagen deposition.

How it is studied to work

• 1. Bioavailable Cu(II) Tripeptide Delivery Coordinates copper(II) ions via N-terminal Ala-His-Lys donor nitrogens for targeted cellular uptake.
• 2. VEGF & Bcl-2 Pathway Upregulation Stimulates endothelial VEGF secretion and elevates the Bcl-2/Bax survival ratio in cultured dermal papilla cells.
• 3. TGF-Beta1 / Caspase-3 Attenuation Down-regulates catagen-associated TGF-beta1 and cleaved caspase-3 while promoting ECM proteoglycan synthesis.

Lab links

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Corex Vitality™ supplies research peptides for laboratory use only. This page is an educational explainer of molecular identity and published research pathways. It is not medical advice and does not recommend human use.