Research use only. For in-vitro and laboratory research. Not for human or veterinary use. No aliquoting guidance is provided.

IGF-1 LR3 Research Video Explainer

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This short video explains IGF-1 LR3 as a research compound. IGF-1 LR3 is 83-Amino-Acid Low-IGFBP-Affinity Insulin-Like Growth Factor-1 Receptor Agonist. It covers its molecular identity (CAS 143045-27-6, 9111.60 g/mol) and the pathways studied in laboratory models. For in-vitro and laboratory research use only. Not for human or veterinary use.

Identity

What researchers study it for

• Studying Glu3→Arg3 substitution + 13-aa N-terminal extension that reduces IGF-Binding Protein (IGFBP-1–6) affinity by >100-fold.
• Investigating sustained IGF-1 Receptor (IGF-1R) tyrosine kinase autophosphorylation in myoblast and fibroblast cultures.
• Examining PI3K/Akt/mTORC1 protein synthesis and MAPK/ERK satellite-cell proliferation pathways in vitro.

How it is studied to work

• 1. Bypass of Inhibitory IGFBPs Arg3 and the 13-aa N-terminal extension prevent sequestration by extracellular IGF-binding proteins (IGFBPs).
• 2. IGF-1R Beta-Subunit Phosphorylation Binds the alpha2beta2 transmembrane IGF-1 receptor, triggering intrinsic tyrosine kinase autophosphorylation.
• 3. IRS-1 / PI3K / Akt / mTORC1 Cascade Recruits IRS-1 to activate PI3K-Akt-mTORC1 translation initiation and MAPK/ERK mitogenic signalling.

Lab links

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Corex Vitality™ supplies research peptides for laboratory use only. This page is an educational explainer of molecular identity and published research pathways. It is not medical advice and does not recommend human use.