MOTS-c Research Video Explainer

For in-vitro and laboratory research use only. Not for human or veterinary use. Nothing on this page is medical advice.

This short video explains MOTS-c as a research compound. MOTS-c is 16-Amino-Acid Mitochondrial-Derived Peptide (12S rRNA Mitokine). It covers its molecular identity (CAS 1627580-64-6, 2174.61 g/mol) and the pathways studied in laboratory models.

Out of stock at the moment. The video is still here to watch.

Key facts

What MOTS-c is studied for

• Studying mitochondrial-encoded open reading frame (sORF) retrograde mitokine signalling to the nucleus.
• Investigating folate-methionine cycle modulation, endogenous AICAR accumulation and AMPK activation.
• Examining exercise-mimetic glucose uptake (GLUT4 translocation) and metabolic stress resilience.

What the video covers

Each slide in the 60-second explainer follows one line of published laboratory work, not a medical outcome.

• 1. Folate Cycle & Purine Biosynthesis Block Inhibits the folate-methionine cycle at 5-methyl-THF, elevating endogenous AICAR levels.
• 2. Allosteric AMPK Phosphorylation Elevated AICAR activates AMP-activated protein kinase (AMPK) and downstream SIRT1/PGC-1alpha.
• 3. Stress-Induced Nuclear Translocation Translocates to the nucleus under metabolic stress to bind ARE/NRF2 stress-response promoters.

Related research videos

• NAD+ (Nicotinamide Adenine Dinucleotide) research video
• SS-31 (Elamipretide) research video
• Epitalon / Epithalon (AEDG Peptide) research video
• All 164 peptide research videos

Batch checks and handling

Every vial carries a report number. Match it to its certificate on the COA verification page before you start work. Lyophilised vials are best kept sealed, dry and at −20 °C or colder, away from light. Reconstitution and storage are covered step by step in our reconstitution and storage guide.

Corex Vitality™ supplies MOTS-c strictly for in-vitro laboratory research by adults aged 18 or over. It is not a medicine, it is not for human or veterinary use, and no information on this page describes use in people or animals. Read the full terms of sale.